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A Salt Bridge in Intracellular Loop 2 Is Essential for Folding of Human P-Glycoprotein
[Image: see text] There is no high-resolution structure of the human P-glycoprotein (P-gp, ABCB1) drug pump. Homology models based on the crystal structures of mouse and Caenorhabditis elegans P-gps show extensive contacts between intracellular loop 2 (ICL2, in the first transmembrane domain) and th...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3656768/ https://ncbi.nlm.nih.gov/pubmed/23634976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400425k |
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