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Locking Intracellular Helices 2 and 3 Together Inactivates Human P-glycoprotein
The P-glycoprotein (P-gp) drug pump (ABCB1) has two transmembrane domains and two nucleotide-binding domains (NBDs). Coupling of the drug-binding sites in the transmembrane domains to the NBDs occurs through interaction of the intracellular helices (IHs) with residues in the NBDs (IH1/IH4/NBD1 and I...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3879546/ https://ncbi.nlm.nih.gov/pubmed/24275649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.527804 |
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