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The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoprotein
P-glycoprotein (P-gp; ABCB1) is an ABC drug pump that protects us from toxic compounds. It is clinically important because it confers multidrug resistance. The homologous halves of P-gp each contain a transmembrane (TM) domain (TMD) with 6 TM segments followed by a nucleotide-binding domain (NBD). T...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4505440/ https://ncbi.nlm.nih.gov/pubmed/25987565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.652602 |
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