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Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket
P-glycoprotein (P-gp; ABCB1) actively transports a broad range of structurally unrelated compounds out of the cell. An important step in the transport cycle is coupling of drug binding with ATP hydrolysis. Drug substrates such as verapamil bind in a common drug-binding pocket at the interface betwee...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1482826/ https://ncbi.nlm.nih.gov/pubmed/16492138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060012 |
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