Mapping the Binding Site of the Inhibitor Tariquidar That Stabilizes the First Transmembrane Domain of P-glycoprotein

Antzeko izenburuak

• Processing Mutations Disrupt Interactions between the Nucleotide Binding and Transmembrane Domains of P-glycoprotein and the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)
  nork: Loo, Tip W., et al.
  Argitaratua: (2008)
• Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site
  nork: Loo, Tip W., et al.
  Argitaratua: (2002)
• Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket
  nork: Loo, Tip W., et al.
  Argitaratua: (2006)
• Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket
  nork: Loo, Tip W., et al.
  Argitaratua: (2006)
• The ATPase Activity of the P-glycoprotein Drug Pump Is Highly Activated When the N-terminal and Central Regions of the Nucleotide-binding Domains Are Linked Closely Together
  nork: Loo, Tip W., et al.
  Argitaratua: (2012)