Unexpected pieces to the senescence puzzle

Tekijä Cichowski, Karen, Hahn, William C.
Julkaistu 2008

Identifying the ubiquitin ligase complex that regulates the NF1 tumor suppressor and Ras

Tekijä Hollstein, Pablo E., Cichowski, Karen
Julkaistu 2013

SPRED proteins provide a NF-ty link to Ras suppression

Tekijä McClatchey, Andrea I., Cichowski, Karen
Julkaistu 2012

Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is

Tekijä Liao, Sida, Maertens, Ophélia, Cichowski, Karen, Elledge, Stephen J.
Julkaisussa Genes Dev (2018)

Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor

Tekijä Cichowski, Karen, Santiago, Sabrina, Jardim, Melanie, Johnson, Bryan W., Jacks, Tyler
Julkaistu 2003

The NF1 tumor suppressor critically regulates TSC2 and mTOR

Tekijä Johannessen, Cory M., Reczek, Elizabeth E., James, Marianne F., Brems, Hilde, Legius, Eric, Cichowski, Karen
Julkaistu 2005

Defining key signaling nodes and therapeutic biomarkers in NF1-mutant cancers

Tekijä Malone, Clare F., Fromm, Jody A., Maertens, Ophélia, DeRaedt, Thomas, Ingraham, Rachel, Cichowski, Karen
Julkaisussa Cancer Discov (2014)

K-ras is an essential gene in the mouse with partial functional overlap with N-ras

Tekijä Johnson, Leisa, Greenbaum, Doron, Cichowski, Karen, Mercer, Kim, Murphy, Elizabeth, Schmitt, Eric, Bronson, Roderick T., Umanoff, Heywood, Edelmann, Windfried, Kucherlapati, Raju, Jacks, Tyler
Julkaistu 1997

ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines

Tekijä Engelman, Jeffrey A., Jänne, Pasi A., Mermel, Craig, Pearlberg, Joseph, Mukohara, Toru, Fleet, Christina, Cichowski, Karen, Johnson, Bruce E., Cantley, Lewis C.
Julkaistu 2005

Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers

Tekijä Lock, Rebecca, Ingraham, Rachel, Maertens, Ophélia, Miller, Abigail L., Weledji, Nelly, Legius, Eric, Konicek, Bruce M., Yan, Sau-Chi B., Graff, Jeremy R., Cichowski, Karen
Julkaisussa J Clin Invest (2016)

A negative feedback signaling network underlies oncogene-induced senescence

Tekijä Courtois-Cox, Stéphanie, Genther Williams, Sybil M., Reczek, Elizabeth E., Johnson, Bryan W., McGillicuddy, Lauren T., Johannessen, Cory M., Hollstein, Pablo, MacCollin, Mia, Cichowski, Karen
Julkaistu 2006

The RasGAP Gene, RASAL2, is a Tumor and Metastasis Suppressor

Tekijä McLaughlin, Sara Koenig, Olsen, Sarah Naomi, Dake, Benjamin, De Raedt, Thomas, Lim, Elgene, Bronson, Roderick Terry, Beroukhim, Rameen, Polyak, Kornelia, Brown, Myles, Kuperwasser, Charlotte, Cichowski, Karen
Julkaistu 2013

mTOR and HDAC inhibitors converge on the TXNIP/thioredoxin pathway to cause catastrophic oxidative stress and regression of RAS-driven tumors

Tekijä Malone, Clare F., Emerson, Chloe, Ingraham, Rachel, Barbosa, William, Guerra, Stephanie, Yoon, Haejin, Liu, Lin L., Michor, Franziska, Haigis, Marcia, Macleod, Kay F., Maertens, Ophélia, Cichowski, Karen
Julkaisussa Cancer Discov (2017)

Imaging Mass Spectrometry Reveals Tumor Metabolic Heterogeneity

Tekijä Zhang, Yang, Guillermier, Christelle, De Raedt, Thomas, Cox, Andrew G., Maertens, Ophelia, Yimlamai, Dean, Lun, Mingyue, Whitney, Adam, Maas, Richard L., Goessling, Wolfram, Cichowski, Karen, Steinhauser, Matthew L.
Julkaisussa iScience (2020)

Elucidating distinct roles for NF1 in melanomagenesis

Tekijä Maertens, Ophélia, Johnson, Bryan, Hollstein, Pablo, Frederick, Dennie T., Cooper, Zachary A., Messiaen, Ludwine, Bronson, Roderick T., McMahon, Martin, Granter, Scott, Flaherty, Keith, Wargo, Jennifer A., Marais, Richard, Cichowski, Karen
Julkaistu 2012

Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance

Tekijä Takahashi, Nobuaki, Chen, Hsing-Yu, Harris, Isaac S., Stover, Daniel G., Selfors, Laura M., Bronson, Roderick T., Deraedt, Thomas, Cichowski, Karen, Welm, Alana L., Mori, Yasuo, Mills, Gordon B., Brugge, Joan S.
Julkaisussa Cancer Cell (2018)

IL1α antagonizes IL1β and promotes adaptive immune rejection of malignant tumors

Tekijä Tian, Tian, Lofftus, Serena, Pan, Youdong, Stingley, Claire A, King, Sandra L, Zhao, Jingxia, Pan, Timothy Y, Lock, Rebecca, Marglous, Jacob W, Liu, Kevin, Widlund, Hans R, Fuhlbrigge, Robert, Cichowski, Karen, Kupper, Thomas S
Julkaisussa Cancer Immunol Res (2020)

Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy

Tekijä Montero, Joan, Sarosiek, Kristopher A., DeAngelo, Joseph D., Maertens, Ophélia, Ryan, Jeremy, Ercan, Dalia, Piao, Huiying, Horowitz, Neil S., Berkowitz, Ross S., Matulonis, Ursula, Jänne, Pasi A., Amrein, Philip C., Cichowski, Karen, Drapkin, Ronny, Letai, Anthony
Julkaisussa Cell (2015)

A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies

Tekijä Maertens, Ophélia, McCurrach, Mila E., Braun, Benjamin S., De Raedt, Thomas, Epstein, Inbal, Huang, Tannie Q., Lauchle, Jennifer O., Lee, Hyerim, Wu, Jianqiang, Cripe, Timothy P., Clapp, D. Wade, Ratner, Nancy, Shannon, Kevin, Cichowski, Karen
Julkaisussa Cancer Res (2017)

An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and NF-κB

Tekijä Min, Junxia, Zaslavsky, Alexander, Fedele, Giuseppe, McLaughlin, Sara K., Reczek, Elizabeth E., De Raedt, Thomas, Guney, Isil, Strochlic, David E., Laura, E., Beroukhim, Rameen, Bronson, Roderick T., Ryeom, Sandra, Hahn, William C., Loda, Massimo, Cichowski, Karen
Julkaistu 2010