Through Reducing ROS Production, IL-10 Suppresses Caspase-1-Dependent IL-1β Maturation, thereby Preventing Chronic Neuroinflammation and Neurodegeneration

Por Gao, Yun, Tu, Dezhen, Yang, Ru, Chu, Chun-Hsien, Hong, Jau-Shyong, Gao, Hui-Ming
Publicado no Int J Mol Sci (2020)

Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91(phox )subunit of NADPH oxidase

Por Wang, Qingshan, Zhou, Hui, Gao, Huiming, Chen, Shih-Heng, Chu, Chun-Hsien, Wilson, Belinda, Hong, Jau-Shyong
Publicado em 2012

Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases

Por Wang, Qingshan, Chu, Chun-Hsien, Oyarzabal, Esteban, Jiang, Lulu, Chen, Shih-Heng, Wilson, Belinda, Qian, Li, Hong, Jau-Shyong
Publicado em 2014

α-Synuclein, a chemoattractant, directs microglial migration via H(2)O(2)-dependent Lyn phosphorylation

Por Wang, Shijun, Chu, Chun-Hsien, Stewart, Tessandra, Ginghina, Carmen, Wang, Yifei, Nie, Hui, Guo, Mingri, Wilson, Belinda, Hong, Jau-Shyong, Zhang, Jing
Publicado no Proc Natl Acad Sci U S A (2015)

Microglial Regulation of Immunological and Neuroprotective Functions of Astroglia

Por Chen, Shih-Heng, Oyarzabal, Esteban A., Sung, Yueh-Feng, Chu, Chun-Hsien, Wang, Qingshan, Chen, Shiou-Lan, Lu, Ru-Band, Hong, Jau-Shyong
Publicado no Glia (2014)

Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson’s disease models

Por Wang, Qingshan, Qian, Li, Chen, Shih-Heng, Chu, Chun-Hsien, Wilson, Belinda, Oyarzabal, Esteban, Ali, Syed, Robinson, Bonnie, Rao, Deepa, Hong, Jau-Shyong
Publicado no Brain (2015)

Low-dose memantine attenuated morphine addictive behavior through its anti-inflammation and neurotrophic effects in rats

Por Chen, Shiou-Lan, Tao, Pao-Luh, Chu, Chun-Hsien, Chen, Shih-Heng, Wu, Hsiang-En, Tseng, Leon F., Hong, Jau-Shyong, Lu, Ru-Band
Publicado em 2011

A novel role of microglial NADPH oxidase in mediating extra-synaptic function of norepinephrine in regulating brain immune homeostasis

Por Jiang, Lulu, Chen, Shih-Heng, Chu, Chun-Hsien, Wang, Shi-Jun, Oyarzabal, Esteban, Wilson, Belinda, Sanders, Virginia, Xie, Keqin, Wang, Qingshan, Hong, Jau-Shyong
Publicado no Glia (2015)

Identification of a specific α-synuclein peptide (α-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons

Por Wang, Shijun, Chu, Chun-Hsien, Guo, Mingri, Jiang, Lulu, Nie, Hui, Zhang, Wei, Wilson, Belinda, Yang, Li, Stewart, Tessandra, Hong, Jau-Shyong, Zhang, Jing
Publicado no J Neuroinflammation (2016)

Substance P Exacerbates Dopaminergic Neurodegeneration through Neurokinin-1 Receptor-Independent Activation of Microglial NADPH Oxidase

Por Wang, Qingshan, Chu, Chun-Hsien, Qian, Li, Chen, Shih-Heng, Wilson, Belinda, Oyarzabal, Esteban, Jiang, Lulu, Ali, Syed, Robinson, Bonnie, Kim, Hyoung-Chun, Hong, Jau-Shyong
Publicado em 2014

PGE(2) inhibits IL-10 production via EP2-mediated β-arrestin signaling in neuroinflammatory condition

Por Chu, Chun-Hsien, Chen, Shih-Heng, Wang, Qingshan, Langenbach, Robert, Li, Hong, Zeldin, Darryl, Chen, Shiou-Lan, Wang, Shijun, Gao, Huiming, Lu, Ru-Band, Hong, Jau-Shyong
Publicado no Mol Neurobiol (2014)

WWOX Phosphorylation, Signaling, and Role in Neurodegeneration

Por Liu, Chan-Chuan, Ho, Pei-Chuan, Lee, I.-Ting, Chen, Yu-An, Chu, Chun-Hsien, Teng, Chih-Chuan, Wu, Sheng-Nan, Sze, Chun-I., Chiang, Ming-Fu, Chang, Nan-Shan
Publicado no Front Neurosci (2018)

Executive functions in elderly men

Por Liu, Mu-En, Chang, Yun-Hsuan, Ku, Yan-Chiou, Lee, Sheng-Yu, Huang, Chih-Chung, Chen, Shiou-Lan, Chen, Shih-Heng, Chu, Chun-Hsien, Liu, Wen-Chien, Lu, Ru-Band
Publicado em 2011

The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese heroin-dependent patients

Por Chen, Shiou-Lan, Lee, Sheng-Yu, Chang, Yun-Hsuan, Wang, Tzu-Yun, Chen, Shih-Heng, Chu, Chun-Hsien, Chen, Po See, Yang, Yen Kuang, Hong, Jau-Shyong, Lu, Ru-Band
Publicado no Sci Rep (2015)

Akt mediates 17β-estradiol and/or estrogen receptor-α inhibition of LPS-induced tumor necresis factor-α expression and myocardial cell apoptosis by suppressing the JNK1/2-NFκB path...

Por Liu, Chung-Jung, Lo, Jeng-Fan, Kuo, Chia-Hua, Chu, Chun-Hsien, Chen, Li-Ming, Tsai, Fuu-Jen, Tsai, Chang-Hai, Tzang, Bor-Show, Kuo, Wei-Wen, Huang, Chih-Yang
Publicado no J Cell Mol Med (2009)

Neurons and astroglia govern microglial endotoxin tolerance through macrophage colony-stimulating factor receptor-mediated ERK1/2 signals

Por Chu, Chun-Hsien, Wang, Shijun, Li, Chia-Ling, Chen, Shih-Heng, Hu, Chih-Fen, Chung, Yi-Lun, Chen, Shiou-Lan, Wang, Qingshan, Lu, Ru-Band, Gao, Hui-Ming, Hong, Jau-Shyong
Publicado no Brain Behav Immun (2016)

Physiological concentration of prostaglandin E(2) exerts anti-inflammatory effects by inhibiting microglial production of superoxide through a novel pathway

Por Chen, Shih-Heng, Sung, Yueh-Feng, Oyarzabal, Esteban A., Tan, Yu-Mei, Leonard, Jeremy, Guo, Mingri, Li, Shuo, Wang, Qingshan, Chu, Chun-Hsien, Chen, Shiou-Lan, Lu, Ru-Band, Hong, Jau-Shyong
Publicado no Mol Neurobiol (2018)

The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia

Por Chen, Shiou-Lan, Lee, Sheng-Yu, Chang, Yun-Hsuan, Chen, Shih-Heng, Chu, Chun-Hsien, Wang, Tzu-Yun, Chen, Po-See, Lee, I-Hui, Yang, Yen-Kuang, Hong, Jau-Shyong, Lu, Ru-Band
Publicado no Prog Neuropsychopharmacol Biol Psychiatry (2014)

Poorer sustained attention in bipolar I than bipolar II disorder

Por Kung, Chian-Huei, Lee, Sheng-Yu, Chang, Yun-Hsuan, Wu, Jo Yung-Wei, Chen, Shiou-Lan, Chen, Shih-Heng, Chu, Chun-Hsien, Lee, I-Hui, Yeh, Tzung-Lieh, Yang, Yen-Kuang, Lu, Ru-Band
Publicado em 2010

Interaction between Serotonin Transporter and Serotonin Receptor 1 B genes polymorphisms may be associated with antisocial alcoholism

Por Wang, Tzu-Yun, Lee, Sheng-Yu, Chen, Shiou-Lan, Chang, Yun-Hsuan, Chen, Shih-Heng, Chu, Chun-Hsien, Huang, San-Yuan, Tzeng, Nian-Sheng, Wang, Chen-Lin, Lee, I Hui, Yeh, Tzung Lieh, Yang, Yen Kuang, Lu, Ru-Band
Publicado em 2012