Substance P Exacerbates Dopaminergic Neurodegeneration through Neurokinin-1 Receptor-Independent Activation of Microglial NADPH Oxidase

Although dysregulated substance P (SP) has been implicated in the pathophysiology of Parkinson's disease (PD), how SP affects the survival of dopaminergic neurons remains unclear. Here, we found that mice lacking endogenous SP (TAC1(−/−)), but not those deficient in the SP receptor (neurokinin-...

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Detalhes bibliográficos
Main Authors: Wang, Qingshan, Chu, Chun-Hsien, Qian, Li, Chen, Shih-Heng, Wilson, Belinda, Oyarzabal, Esteban, Jiang, Lulu, Ali, Syed, Robinson, Bonnie, Kim, Hyoung-Chun, Hong, Jau-Shyong
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160779/
https://ncbi.nlm.nih.gov/pubmed/25209287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2238-14.2014
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