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Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases
Activation of microglial NADPH oxidase (NOX2) plays a critical role in mediating neuroinflammation, which is closely linked with the pathogenesis of a variety of neurodegenerative diseases, including Parkinson’s disease (PD). The inhibition of NOX2-generated superoxide has become an effective strate...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4205171/ https://ncbi.nlm.nih.gov/pubmed/25043383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22724 |
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