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Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases

Activation of microglial NADPH oxidase (NOX2) plays a critical role in mediating neuroinflammation, which is closely linked with the pathogenesis of a variety of neurodegenerative diseases, including Parkinson’s disease (PD). The inhibition of NOX2-generated superoxide has become an effective strate...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Wang, Qingshan, Chu, Chun-Hsien, Oyarzabal, Esteban, Jiang, Lulu, Chen, Shih-Heng, Wilson, Belinda, Qian, Li, Hong, Jau-Shyong
פורמט: Artigo
שפה:Inglês
יצא לאור: 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205171/
https://ncbi.nlm.nih.gov/pubmed/25043383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22724
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