Physiological concentration of prostaglandin E(2) exerts anti-inflammatory effects by inhibiting microglial production of superoxide through a novel pathway

This study investigated the physiological regulation of brain immune homeostasis in rat primary neuron-glial cultures by sub-nanomolar concentrations of prostaglandin E2 (PGE(2)). We demonstrated that 0.01 to 10 nM PGE(2) protected dopaminergic neurons against LPS-induced neurotoxicity through a red...

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Veröffentlicht in:Mol Neurobiol
Hauptverfasser: Chen, Shih-Heng, Sung, Yueh-Feng, Oyarzabal, Esteban A., Tan, Yu-Mei, Leonard, Jeremy, Guo, Mingri, Li, Shuo, Wang, Qingshan, Chu, Chun-Hsien, Chen, Shiou-Lan, Lu, Ru-Band, Hong, Jau-Shyong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6119547/
https://ncbi.nlm.nih.gov/pubmed/29492849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-0965-4
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