Identification of a specific α-synuclein peptide (α-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons

BACKGROUND: Misfolded α-synuclein (α-Syn) aggregates participate in the pathogenesis of synucleinopathies, such as Parkinson’s disease. Whereas much is known about how the various domains within full-length α-Syn (FL-α-Syn) contribute to the formation of α-Syn aggregates and therefore to their neuro...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Wang, Shijun, Chu, Chun-Hsien, Guo, Mingri, Jiang, Lulu, Nie, Hui, Zhang, Wei, Wilson, Belinda, Yang, Li, Stewart, Tessandra, Hong, Jau-Shyong, Zhang, Jing
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915166/
https://ncbi.nlm.nih.gov/pubmed/27329107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0606-7
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