Triton X-100 or octyl glucoside inactivates acyl-CoA:cholesterol acyltransferase 1 by dissociating it from a two-fold dimer to a two-fold monomer

Autor Neumann, Bryan, Chang, Catherine C. Y., Chang, Ta-Yuan
Vydáno v Arch Biochem Biophys (2019)

A simple method to disrupt and restore subunit interaction of acyl-CoA:cholesterol acyltransferase 1

Autor Neumann, Bryan, Chang, Catherine C.Y., Chang, Ta-Yuan
Vydáno v MethodsX (2019)

Human Acyl-Coenzyme A:Cholesterol Acyltransferase Expressed in Chinese Hamster Ovary Cells: Membrane Topology and Active Site Location

Autor Lin, Song, Lu, Xiaohui, Chang, Catherine C.Y., Chang, Ta-Yuan
Vydáno 2003

Nanodisc scaffold peptide (NSP(r)) replaces detergent by reconstituting acyl-CoA:cholesterol acyltransferase 1 into peptidiscs

Autor Neumann, Bryan, Chao, Kevin, Chang, Catherine C. Y., Chang, Ta-Yuan
Vydáno v Arch Biochem Biophys (2020)

Acyl-coenzyme A:cholesterol acyltransferases

Autor Chang, Ta-Yuan, Li, Bo-Liang, Chang, Catherine C. Y., Urano, Yasuomi
Vydáno 2009

Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies

Autor Liu, Jay, Chang, Catherine C. Y., Westover, Emily J., Covey, Douglas F., Chang, Ta-Yuan
Vydáno 2005

Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity

Autor Sakashita, Naomi, Chang, Catherine C. Y., Lei, Xiaofeng, Fujiwara, Yukio, Takeya, Motohiro, Chang, Ta-Yuan
Vydáno 2010

Identification of Soat1 as a Quantitative Trait Locus Gene on Mouse Chromosome 1 Contributing to Hyperlipidemia

Autor Lu, Zongji, Yuan, Zuobiao, Miyoshi, Toru, Wang, Qian, Su, Zhiguang, Chang, Catherine C., Shi, Weibin
Vydáno 2011

Inhibiting ACAT1/SOAT1 in Microglia Stimulates Autophagy-Mediated Lysosomal Proteolysis and Increases Aβ1–42 Clearance

Autor Shibuya, Yohei, Chang, Catherine C.Y., Huang, Li-Hao, Bryleva, Elena Y., Chang, Ta-Yuan
Vydáno 2014

Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy

Autor Duong, Michael Tran, Nasrallah, Ilya M., Wolk, David A., Chang, Catherine C. Y., Chang, Ta-Yuan
Vydáno v Front Aging Neurosci (2021)

Binding between the Niemann–Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain

Autor Ohgami, Nobutaka, Ko, Dennis C., Thomas, Matthew, Scott, Matthew P., Chang, Catherine C. Y., Chang, Ta-Yuan
Vydáno 2004

Localization of Human Acyl-Coenzyme A:Cholesterol Acyltransferase-1 (ACAT-1) in Macrophages and in Various Tissues

Autor Sakashita, Naomi, Miyazaki, Akira, Takeya, Motohiro, Horiuchi, Seikoh, Chang, Catherine C. Y., Chang, Ta-Yuan, Takahashi, Kiyoshi
Vydáno 2000

Acyl-Coenzyme A:cholesterol Acyltransferase 1: Significance of Single Nucleotide Polymorphism at Residue 526 and Role of Proline 347 near the Fifth Transmembrane Domain

Autor Huang, Li-Hao, Nishi, Koji, Li, Song, Ho, Thomas, Dong, Ruhong, Chang, Catherine C.Y., Chang, Ta-Yuan
Vydáno 2014

Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): enzymes with multiple sterols as substrates and as activators

Autor Rogers, Maximillian A., Liu, Jay, Song, Bao-Liang, Li, Bo-Liang, Chang, Catherine C.Y., Chang, Ta-Yuan
Vydáno v J Steroid Biochem Mol Biol (2014)

Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex

Autor Urano, Yasuomi, Watanabe, Hiroshi, Murphy, Stephanie R., Shibuya, Yohei, Geng, Yong, Peden, Andrew A., Chang, Catherine C. Y., Chang, Ta Yuan
Vydáno 2008

Acat1 Gene Ablation in Mice Increases Hematopoietic Progenitor Cell Proliferation in Bone Marrow and Causes Leukocytosis

Autor Huang, Li-Hao, Gui, Jingang, Artinger, Erika, Craig, Ruth, Berwin, Brent L., Ernst, Patricia A., Chang, Catherine C.Y., Chang, Ta-Yuan
Vydáno 2013

Partial blockage of sterol biosynthesis with a squalene synthase inhibitor in early postnatal Niemann-Pick type C npc(nih) null mice brains reduces neuronal cholesterol accumulatio...

Autor Reid, Patrick C., Lin, Song, Vanier, Marie T., Ohno-Iwashita, Yoshiko, Harwood, H. James, Hickey, William F., Chang, Catherine C.Y., Chang, Ta-Yuan
Vydáno 2007

Acyl-CoA:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer’s disease mouse and reduces human P301L-tau content at the pre-symp...

Autor Shibuya, Yohei, Niu, Zhaoyang, Bryleva, Elena Y., Harris, Brent T., Murphy, Stephanie R., Kheirollah, Alireza, Bowen, Zachary D., Chang, Catherine C.Y., Chang, Ta-Yuan
Vydáno v Neurobiol Aging (2015)

Myeloid Acat1/Soat1 KO attenuates pro-inflammatory responses in macrophages and protects against atherosclerosis in a model of advanced lesions

Autor Melton, Elaina M., Li, Haibo, Benson, Jalen, Sohn, Paul, Huang, Li-Hao, Song, Bao-Liang, Li, Bo-Liang, Chang, Catherine C. Y., Chang, Ta-Yuan
Vydáno v J Biol Chem (2019)

Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor

Autor Guan, Chengcheng, Niu, Yange, Chen, Si-Cong, Kang, Yunlu, Wu, Jing-Xiang, Nishi, Koji, Chang, Catherine C. Y., Chang, Ta-Yuan, Luo, Tuoping, Chen, Lei
Vydáno v Nat Commun (2020)