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Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity
ACAT1 is normally a resident enzyme in the endoplasmic reticulum (ER). We previously showed that treating macrophages with denatured LDL causes a large increase in ER-derived, ACAT1-positive vesicles. Here, we isolated ER membranes and ER-derived vesicles to examine their ACAT enzyme activity in vit...
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Main Authors: | , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
The American Society for Biochemistry and Molecular Biology
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3035490/ https://ncbi.nlm.nih.gov/pubmed/20460577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M900288 |
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