Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity

ACAT1 is normally a resident enzyme in the endoplasmic reticulum (ER). We previously showed that treating macrophages with denatured LDL causes a large increase in ER-derived, ACAT1-positive vesicles. Here, we isolated ER membranes and ER-derived vesicles to examine their ACAT enzyme activity in vit...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Sakashita, Naomi, Chang, Catherine C. Y., Lei, Xiaofeng, Fujiwara, Yukio, Takeya, Motohiro, Chang, Ta-Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035490/
https://ncbi.nlm.nih.gov/pubmed/20460577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M900288
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados