ACAT1-associated Late Endosomes/Lysosomes Significantly Improve Impaired Intracellular Cholesterol Metabolism and the Survival of Niemann-Pick Type C Mice

We previously demonstrated that macrophages exhibit endoplasmic reticulum fragmentation under cholesterol-rich conditions, which results in the generation of acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1)-associated late endosomes/lysosomes (ACAT1-LE). ACAT1-LE efficiently esterify free chol...

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Main Authors: Kamikawa, Masashi, Lei, XiaoFeng, Fujiwara, Yukio, Nishitsuji, Kazuchika, Mizuta, Hiroshi, Takeya, Motohiro, Sakashita, Naomi
Formato: Artigo
Idioma:Inglês
Publicado: Japan Society of Histochemistry and Cytochemistry 2014
Assuntos:
Regular Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4105798/
https://ncbi.nlm.nih.gov/pubmed/25221362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1267/ahc.13033
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