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Activation Mobilizes the Cholesterol in the Late Endosomes-Lysosomes of Niemann Pick Type C Cells

A variety of intercalating amphipaths increase the chemical activity of plasma membrane cholesterol. To test whether intracellular cholesterol can be similarly activated, we examined NPC1 and NPC2 fibroblasts, since they accumulate large amounts of cholesterol in their late endosomes and lysosomes (...

詳細記述

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書誌詳細
主要な著者: Lange, Yvonne, Ye, Jin, Steck, Theodore L.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262792/
https://ncbi.nlm.nih.gov/pubmed/22276143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030051
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