Inhibiting ACAT1/SOAT1 in Microglia Stimulates Autophagy-Mediated Lysosomal Proteolysis and Increases Aβ1–42 Clearance

Acyl-CoA:cholesterol acyltransferase 1 (ACAT1) is a resident endoplasmic reticulum enzyme that prevents the buildup of cholesterol in membranes by converting it to cholesterol esters. Blocking ACAT1 pharmacologically or by Acat1 gene knock-out (KO) decreases amyloidopathy in mouse models for Alzheim...

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Autors principals: Shibuya, Yohei, Chang, Catherine C.Y., Huang, Li-Hao, Bryleva, Elena Y., Chang, Ta-Yuan
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205563/
https://ncbi.nlm.nih.gov/pubmed/25339759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2567-14.2014
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