Myeloid Acat1/Soat1 KO attenuates pro-inflammatory responses in macrophages and protects against atherosclerosis in a model of advanced lesions

Cholesterol esters are a key ingredient of foamy cells in atherosclerotic lesions; their formation is catalyzed by two enzymes: acyl-CoA:cholesterol acyltransferases (ACATs; also called sterol O-acyltransferases, or SOATs) ACAT1 and ACAT2. ACAT1 is present in all body cells and is the major isoenzym...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Melton, Elaina M., Li, Haibo, Benson, Jalen, Sohn, Paul, Huang, Li-Hao, Song, Bao-Liang, Li, Bo-Liang, Chang, Catherine C. Y., Chang, Ta-Yuan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6816086/
https://ncbi.nlm.nih.gov/pubmed/31495784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010564
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