Acat1 Gene Ablation in Mice Increases Hematopoietic Progenitor Cell Proliferation in Bone Marrow and Causes Leukocytosis

OBJECTIVE: To investigate the role of acyl-CoA:cholesterol acyltransferase 1 (ACAT1) in hematopoiesis. APPROACH AND RESULTS: ACAT1 converts cellular cholesterol to cholesteryl esters for storage in multiple cell types and is a potential drug target for human diseases. In mouse models for atheroscler...

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Main Authors: Huang, Li-Hao, Gui, Jingang, Artinger, Erika, Craig, Ruth, Berwin, Brent L., Ernst, Patricia A., Chang, Catherine C.Y., Chang, Ta-Yuan
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882116/
https://ncbi.nlm.nih.gov/pubmed/23846496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.301080
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