Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors

The Mixed Lineage Leukemia (Mll) gene is essential for embryonic hematopoietic stem cell (HSC) development but its role during adult hematopoiesis is unknown. Using an inducible knockout model, we demonstrate that Mll is essential for the maintenance of adult HSCs and progenitors, with fatal bone ma...

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Main Authors: Jude, Craig D., Climer, Leslie, Xu, Diyong, Artinger, Erika, Fisher, Jill, Ernst, Patricia
格式: Artigo
語言:Inglês
出版: 2007
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234224/
https://ncbi.nlm.nih.gov/pubmed/18371366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2007.05.019
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