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Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells
Mixed Lineage Leukemia (MLL1) translocations encode fusion proteins retaining the N terminus of MLL1, which interacts with the tumor suppressor, menin. This interaction is essential for leukemogenesis and thus is a promising drug target. However, wild-type MLL1 plays a critical role in sustaining he...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3778547/ https://ncbi.nlm.nih.gov/pubmed/23908472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-03-486647 |
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