Distinct signaling programs control human hematopoietic stem cell survival and proliferation

Several growth factors (GFs) that together promote quiescent human hematopoietic stem cell (HSC) expansion ex vivo have been identified; however, the molecular mechanisms by which these GFs regulate the survival, proliferation. and differentiation of human HSCs remain poorly understood. We now descr...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Knapp, David J. H. F., Hammond, Colin A., Aghaeepour, Nima, Miller, Paul H., Pellacani, Davide, Beer, Philip A., Sachs, Karen, Qiao, Wenlian, Wang, WeiJia, Humphries, R. Keith, Sauvageau, Guy, Zandstra, Peter W., Bendall, Sean C., Nolan, Garry P., Hansen, Carl, Eaves, Connie J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5271174/
https://ncbi.nlm.nih.gov/pubmed/27827829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-09-740654
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