Blood stem cell fate regulation by Delta-1–mediated rewiring of IL-6 paracrine signaling

Increasing evidence supports the importance of cell extrinsic regulation in stem cell fate control. Hematopoietic stem cells (HSC) are responsive to local signals from their niche and to systemic feedback from progenitors and mature cells. The Notch ligand Delta-1 (DL1), a key component of the stem...

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Detalhes bibliográficos
Main Authors: Csaszar, Elizabeth, Wang, Weijia, Usenko, Tatiana, Qiao, Wenlian, Delaney, Colleen, Bernstein, Irwin D., Zandstra, Peter W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907753/
https://ncbi.nlm.nih.gov/pubmed/24243972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-08-520445
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