Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells

Mixed Lineage Leukemia (MLL1) translocations encode fusion proteins retaining the N terminus of MLL1, which interacts with the tumor suppressor, menin. This interaction is essential for leukemogenesis and thus is a promising drug target. However, wild-type MLL1 plays a critical role in sustaining he...

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Bibliografiske detaljer
Main Authors: Li, Bin E., Gan, Tao, Meyerson, Matthew, Rabbitts, Terence H., Ernst, Patricia
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2013
Fag:
Hematopoiesis and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778547/
https://ncbi.nlm.nih.gov/pubmed/23908472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-03-486647
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