ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

Cholesterol metabolism has been implicated in the pathogenesis of several neurodegenerative diseases, including the abnormal accumulation of amyloid-β, one of the pathological hallmarks of Alzheimer disease (AD). Acyl-CoA:cholesterol acyltransferases (ACAT1 and ACAT2) are two enzymes that convert fr...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Bryleva, Elena Y., Rogers, Maximillian A., Chang, Catherine C.Y., Buen, Floyd, Harris, Brent T., Rousselet, Estelle, Seidah, Nabil G., Oddo, Salvatore, LaFerla, Frank M., Spencer, Thomas A., Hickey, William F., Chang, Ta-Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840286/
https://ncbi.nlm.nih.gov/pubmed/20133765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913828107
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados