ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

Cholesterol metabolism has been implicated in the pathogenesis of several neurodegenerative diseases, including the abnormal accumulation of amyloid-β, one of the pathological hallmarks of Alzheimer disease (AD). Acyl-CoA:cholesterol acyltransferases (ACAT1 and ACAT2) are two enzymes that convert fr...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Bryleva, Elena Y., Rogers, Maximillian A., Chang, Catherine C.Y., Buen, Floyd, Harris, Brent T., Rousselet, Estelle, Seidah, Nabil G., Oddo, Salvatore, LaFerla, Frank M., Spencer, Thomas A., Hickey, William F., Chang, Ta-Yuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840286/
https://ncbi.nlm.nih.gov/pubmed/20133765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913828107
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi