Triton X-100 or octyl glucoside inactivates acyl-CoA:cholesterol acyltransferase 1 by dissociating it from a two-fold dimer to a two-fold monomer

Por Neumann, Bryan, Chang, Catherine C. Y., Chang, Ta-Yuan
Publicado no Arch Biochem Biophys (2019)

A simple method to disrupt and restore subunit interaction of acyl-CoA:cholesterol acyltransferase 1

Por Neumann, Bryan, Chang, Catherine C.Y., Chang, Ta-Yuan
Publicado no MethodsX (2019)

Human Acyl-Coenzyme A:Cholesterol Acyltransferase Expressed in Chinese Hamster Ovary Cells: Membrane Topology and Active Site Location

Por Lin, Song, Lu, Xiaohui, Chang, Catherine C.Y., Chang, Ta-Yuan
Publicado em 2003

Nanodisc scaffold peptide (NSP(r)) replaces detergent by reconstituting acyl-CoA:cholesterol acyltransferase 1 into peptidiscs

Por Neumann, Bryan, Chao, Kevin, Chang, Catherine C. Y., Chang, Ta-Yuan
Publicado no Arch Biochem Biophys (2020)

Acyl-coenzyme A:cholesterol acyltransferases

Por Chang, Ta-Yuan, Li, Bo-Liang, Chang, Catherine C. Y., Urano, Yasuomi
Publicado em 2009

Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies

Por Liu, Jay, Chang, Catherine C. Y., Westover, Emily J., Covey, Douglas F., Chang, Ta-Yuan
Publicado em 2005

Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity

Por Sakashita, Naomi, Chang, Catherine C. Y., Lei, Xiaofeng, Fujiwara, Yukio, Takeya, Motohiro, Chang, Ta-Yuan
Publicado em 2010

Identification of Soat1 as a Quantitative Trait Locus Gene on Mouse Chromosome 1 Contributing to Hyperlipidemia

Por Lu, Zongji, Yuan, Zuobiao, Miyoshi, Toru, Wang, Qian, Su, Zhiguang, Chang, Catherine C., Shi, Weibin
Publicado em 2011

Inhibiting ACAT1/SOAT1 in Microglia Stimulates Autophagy-Mediated Lysosomal Proteolysis and Increases Aβ1–42 Clearance

Por Shibuya, Yohei, Chang, Catherine C.Y., Huang, Li-Hao, Bryleva, Elena Y., Chang, Ta-Yuan
Publicado em 2014

Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy

Por Duong, Michael Tran, Nasrallah, Ilya M., Wolk, David A., Chang, Catherine C. Y., Chang, Ta-Yuan
Publicado no Front Aging Neurosci (2021)

Binding between the Niemann–Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain

Por Ohgami, Nobutaka, Ko, Dennis C., Thomas, Matthew, Scott, Matthew P., Chang, Catherine C. Y., Chang, Ta-Yuan
Publicado em 2004

Localization of Human Acyl-Coenzyme A:Cholesterol Acyltransferase-1 (ACAT-1) in Macrophages and in Various Tissues

Por Sakashita, Naomi, Miyazaki, Akira, Takeya, Motohiro, Horiuchi, Seikoh, Chang, Catherine C. Y., Chang, Ta-Yuan, Takahashi, Kiyoshi
Publicado em 2000

Acyl-Coenzyme A:cholesterol Acyltransferase 1: Significance of Single Nucleotide Polymorphism at Residue 526 and Role of Proline 347 near the Fifth Transmembrane Domain

Por Huang, Li-Hao, Nishi, Koji, Li, Song, Ho, Thomas, Dong, Ruhong, Chang, Catherine C.Y., Chang, Ta-Yuan
Publicado em 2014

Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): enzymes with multiple sterols as substrates and as activators

Por Rogers, Maximillian A., Liu, Jay, Song, Bao-Liang, Li, Bo-Liang, Chang, Catherine C.Y., Chang, Ta-Yuan
Publicado no J Steroid Biochem Mol Biol (2014)

Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex

Por Urano, Yasuomi, Watanabe, Hiroshi, Murphy, Stephanie R., Shibuya, Yohei, Geng, Yong, Peden, Andrew A., Chang, Catherine C. Y., Chang, Ta Yuan
Publicado em 2008

Acat1 Gene Ablation in Mice Increases Hematopoietic Progenitor Cell Proliferation in Bone Marrow and Causes Leukocytosis

Por Huang, Li-Hao, Gui, Jingang, Artinger, Erika, Craig, Ruth, Berwin, Brent L., Ernst, Patricia A., Chang, Catherine C.Y., Chang, Ta-Yuan
Publicado em 2013

Partial blockage of sterol biosynthesis with a squalene synthase inhibitor in early postnatal Niemann-Pick type C npc(nih) null mice brains reduces neuronal cholesterol accumulatio...

Por Reid, Patrick C., Lin, Song, Vanier, Marie T., Ohno-Iwashita, Yoshiko, Harwood, H. James, Hickey, William F., Chang, Catherine C.Y., Chang, Ta-Yuan
Publicado em 2007

Acyl-CoA:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer’s disease mouse and reduces human P301L-tau content at the pre-symp...

Por Shibuya, Yohei, Niu, Zhaoyang, Bryleva, Elena Y., Harris, Brent T., Murphy, Stephanie R., Kheirollah, Alireza, Bowen, Zachary D., Chang, Catherine C.Y., Chang, Ta-Yuan
Publicado no Neurobiol Aging (2015)

Myeloid Acat1/Soat1 KO attenuates pro-inflammatory responses in macrophages and protects against atherosclerosis in a model of advanced lesions

Por Melton, Elaina M., Li, Haibo, Benson, Jalen, Sohn, Paul, Huang, Li-Hao, Song, Bao-Liang, Li, Bo-Liang, Chang, Catherine C. Y., Chang, Ta-Yuan
Publicado no J Biol Chem (2019)

Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor

Por Guan, Chengcheng, Niu, Yange, Chen, Si-Cong, Kang, Yunlu, Wu, Jing-Xiang, Nishi, Koji, Chang, Catherine C. Y., Chang, Ta-Yuan, Luo, Tuoping, Chen, Lei
Publicado no Nat Commun (2020)