Triton X-100 or octyl glucoside inactivates acyl-CoA:cholesterol acyltransferase 1 by dissociating it from a two-fold dimer to a two-fold monomer

by Neumann, Bryan, Chang, Catherine C. Y., Chang, Ta-Yuan
Published in Arch Biochem Biophys (2019)

A simple method to disrupt and restore subunit interaction of acyl-CoA:cholesterol acyltransferase 1

by Neumann, Bryan, Chang, Catherine C.Y., Chang, Ta-Yuan
Published in MethodsX (2019)

Human Acyl-Coenzyme A:Cholesterol Acyltransferase Expressed in Chinese Hamster Ovary Cells: Membrane Topology and Active Site Location

by Lin, Song, Lu, Xiaohui, Chang, Catherine C.Y., Chang, Ta-Yuan
Published 2003

Nanodisc scaffold peptide (NSP(r)) replaces detergent by reconstituting acyl-CoA:cholesterol acyltransferase 1 into peptidiscs

by Neumann, Bryan, Chao, Kevin, Chang, Catherine C. Y., Chang, Ta-Yuan
Published in Arch Biochem Biophys (2020)

Acyl-coenzyme A:cholesterol acyltransferases

by Chang, Ta-Yuan, Li, Bo-Liang, Chang, Catherine C. Y., Urano, Yasuomi
Published 2009

Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies

by Liu, Jay, Chang, Catherine C. Y., Westover, Emily J., Covey, Douglas F., Chang, Ta-Yuan
Published 2005

Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity

by Sakashita, Naomi, Chang, Catherine C. Y., Lei, Xiaofeng, Fujiwara, Yukio, Takeya, Motohiro, Chang, Ta-Yuan
Published 2010

Identification of Soat1 as a Quantitative Trait Locus Gene on Mouse Chromosome 1 Contributing to Hyperlipidemia

by Lu, Zongji, Yuan, Zuobiao, Miyoshi, Toru, Wang, Qian, Su, Zhiguang, Chang, Catherine C., Shi, Weibin
Published 2011

Inhibiting ACAT1/SOAT1 in Microglia Stimulates Autophagy-Mediated Lysosomal Proteolysis and Increases Aβ1–42 Clearance

by Shibuya, Yohei, Chang, Catherine C.Y., Huang, Li-Hao, Bryleva, Elena Y., Chang, Ta-Yuan
Published 2014

Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy

by Duong, Michael Tran, Nasrallah, Ilya M., Wolk, David A., Chang, Catherine C. Y., Chang, Ta-Yuan
Published in Front Aging Neurosci (2021)

Binding between the Niemann–Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain

by Ohgami, Nobutaka, Ko, Dennis C., Thomas, Matthew, Scott, Matthew P., Chang, Catherine C. Y., Chang, Ta-Yuan
Published 2004

Localization of Human Acyl-Coenzyme A:Cholesterol Acyltransferase-1 (ACAT-1) in Macrophages and in Various Tissues

by Sakashita, Naomi, Miyazaki, Akira, Takeya, Motohiro, Horiuchi, Seikoh, Chang, Catherine C. Y., Chang, Ta-Yuan, Takahashi, Kiyoshi
Published 2000

Acyl-Coenzyme A:cholesterol Acyltransferase 1: Significance of Single Nucleotide Polymorphism at Residue 526 and Role of Proline 347 near the Fifth Transmembrane Domain

by Huang, Li-Hao, Nishi, Koji, Li, Song, Ho, Thomas, Dong, Ruhong, Chang, Catherine C.Y., Chang, Ta-Yuan
Published 2014

Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): enzymes with multiple sterols as substrates and as activators

by Rogers, Maximillian A., Liu, Jay, Song, Bao-Liang, Li, Bo-Liang, Chang, Catherine C.Y., Chang, Ta-Yuan
Published in J Steroid Biochem Mol Biol (2014)

Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex

by Urano, Yasuomi, Watanabe, Hiroshi, Murphy, Stephanie R., Shibuya, Yohei, Geng, Yong, Peden, Andrew A., Chang, Catherine C. Y., Chang, Ta Yuan
Published 2008

Acat1 Gene Ablation in Mice Increases Hematopoietic Progenitor Cell Proliferation in Bone Marrow and Causes Leukocytosis

by Huang, Li-Hao, Gui, Jingang, Artinger, Erika, Craig, Ruth, Berwin, Brent L., Ernst, Patricia A., Chang, Catherine C.Y., Chang, Ta-Yuan
Published 2013

Partial blockage of sterol biosynthesis with a squalene synthase inhibitor in early postnatal Niemann-Pick type C npc(nih) null mice brains reduces neuronal cholesterol accumulatio...

by Reid, Patrick C., Lin, Song, Vanier, Marie T., Ohno-Iwashita, Yoshiko, Harwood, H. James, Hickey, William F., Chang, Catherine C.Y., Chang, Ta-Yuan
Published 2007

Acyl-CoA:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer’s disease mouse and reduces human P301L-tau content at the pre-symp...

by Shibuya, Yohei, Niu, Zhaoyang, Bryleva, Elena Y., Harris, Brent T., Murphy, Stephanie R., Kheirollah, Alireza, Bowen, Zachary D., Chang, Catherine C.Y., Chang, Ta-Yuan
Published in Neurobiol Aging (2015)

Myeloid Acat1/Soat1 KO attenuates pro-inflammatory responses in macrophages and protects against atherosclerosis in a model of advanced lesions

by Melton, Elaina M., Li, Haibo, Benson, Jalen, Sohn, Paul, Huang, Li-Hao, Song, Bao-Liang, Li, Bo-Liang, Chang, Catherine C. Y., Chang, Ta-Yuan
Published in J Biol Chem (2019)

Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor

by Guan, Chengcheng, Niu, Yange, Chen, Si-Cong, Kang, Yunlu, Wu, Jing-Xiang, Nishi, Koji, Chang, Catherine C. Y., Chang, Ta-Yuan, Luo, Tuoping, Chen, Lei
Published in Nat Commun (2020)