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Binding between the Niemann–Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain

Niemann–Pick type C (NPC) 1 protein plays important roles in moving cholesterol and other lipids out of late endosomes by means of vesicular trafficking, but it is not known whether NPC1 directly interacts with cholesterol. We performed photoaffinity labeling of intact cells expressing fluorescent p...

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Detalhes bibliográficos
Main Authors: Ohgami, Nobutaka, Ko, Dennis C., Thomas, Matthew, Scott, Matthew P., Chang, Catherine C. Y., Chang, Ta-Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC514655/
https://ncbi.nlm.nih.gov/pubmed/15314240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405255101
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