Artificial domain duplication replicates evolutionary history of ketol‐acid reductoisomerases

Por Cahn, Jackson K.B., Brinkmann‐Chen, Sabine, Buller, Andrew R., Arnold, Frances H.
Publicado no Protein Sci (2015)

Discovery of a regioselectivity switch in nitrating P450s guided by MD simulations and Markov models

Por Dodani, Sheel C., Kiss, Gert, Cahn, Jackson K. B., Su, Ye, Pande, Vijay S., Arnold, Frances H.
Publicado no Nat Chem (2016)

Directed evolution mimics allosteric activation by stepwise tuning of the conformational ensemble

Por Buller, Andrew R., van Roye, Paul, Cahn, Jackson K.B., Scheele, Remkes A., Herger, Michael, Arnold, Frances H.
Publicado no J Am Chem Soc (2018)

Structural, Functional, and Spectroscopic Characterization of the Substrate Scope of the Novel Nitrating Cytochrome P450 TxtE

Por Dodani, Sheel C., Cahn, Jackson K. B., Heinisch, Tillmann, Brinkmann-Chen, Sabine, McIntosh, John A., Arnold, Frances H.
Publicado no Chembiochem (2014)

4S-Hydroxylation of insulin at ProB28 accelerates hexamer dissociation and delays fibrillation

Por Lieblich, Seth A., Fang, Katharine Y., Cahn, Jackson K. B., Rawson, Jeffrey, LeBon, Jeanne, Ku, H. Teresa, Tirrell, David A.
Publicado no J Am Chem Soc (2017)

The impact of cryosolution thermal contraction on proteins and protein crystals: volumes, conformation and order

Por Juers, Douglas H., Farley, Christopher A., Saxby, Christopher P., Cotter, Rosemary A., Cahn, Jackson K. B., Holton-Burke, R. Conor, Harrison, Kaitlin, Wu, Zhenguo
Publicado no Acta Crystallogr D Struct Biol (2018)

Cofactor specificity motifs and the induced fit mechanism in Class I ketol-acid reductoisomerases

Por Cahn, Jackson K.B., Brinkmann-Chen, Sabine, Spatzal, Thomas, Wiig, Jared A., Buller, Andrew R., Einsle, Oliver, Hu, Yilin, Ribbe, Markus W., Arnold, Frances H.
Publicado no Biochem J (2015)

General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH

Por Brinkmann-Chen, Sabine, Flock, Tilman, Cahn, Jackson K. B., Snow, Christopher D., Brustad, Eric M., McIntosh, John A., Meinhold, Peter, Zhang, Liang, Arnold, Frances H.
Publicado em 2013

Directed evolution of a bright near-infrared fluorescent rhodopsin using a synthetic chromophore

Por Herwig, Lukas, Rice, Austin J., Bedbrook, Claire N., Zhang, Ruijie K., Lignell, Antti, Cahn, Jackson K. B., Renata, Hans, Dodani, Sheel C., Cho, Inha, Cai, Long, Gradinaru, Viviana, Arnold, Frances H.
Publicado no Cell Chem Biol (2017)

Single-bacterial genomics validates rich and varied specialized metabolism of uncultivated Entotheonella sponge symbionts

Por Mori, Tetsushi, Cahn, Jackson K. B., Wilson, Micheal C., Meoded, Roy A., Wiebach, Vincent, Martinez, Ana Flávia Canovas, Helfrich, Eric J. N., Albersmeier, Andreas, Wibberg, Daniel, Dätwyler, Steven, Keren, Ray, Lavy, Adi, Rückert, Christian, Ilan, Micha, Kalinowski, Jörn, Matsunaga, Shigeki, Takeyama, Haruko, Piel, Jörn
Publicado no Proc Natl Acad Sci U S A (2018)