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Artificial domain duplication replicates evolutionary history of ketol‐acid reductoisomerases

The duplication of protein structural domains has been proposed as a common mechanism for the generation of new protein folds. A particularly interesting case is the class II ketol‐acid reductoisomerase (KARI), which putatively arose from an ancestral class I KARI by duplication of the C‐terminal do...

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Pubblicato in:Protein Sci
Autori principali: Cahn, Jackson K.B., Brinkmann‐Chen, Sabine, Buller, Andrew R., Arnold, Frances H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918412/
https://ncbi.nlm.nih.gov/pubmed/26644020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2852
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