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NADH/NADPH bi-cofactor-utilizing and thermoactive ketol-acid reductoisomerase from Sulfolobus acidocaldarius

Ketol-acid reductoisomerase (KARI) is a bifunctional enzyme in the second step of branched-chain amino acids biosynthetic pathway. Most KARIs prefer NADPH as a cofactor. However, KARI with a preference for NADH is desirable in industrial applications including anaerobic fermentation for the producti...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chen, Chin-Yu, Ko, Tzu-Ping, Lin, Kuan-Fu, Lin, Bo-Lin, Huang, Chun-Hsiang, Chiang, Cheng-Hung, Horng, Jia-Cherng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940873/
https://ncbi.nlm.nih.gov/pubmed/29739976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25361-4
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