Cofactor specificity motifs and the induced fit mechanism in Class I ketol-acid reductoisomerases

Although most sequenced members of the industrially important ketol-acid reductoisomerase (KARI) family are Class I enzymes, structural studies to date have focused primarily on the Class II KARIs, which arose through domain duplication. Here, we present five new crystal structures of Class I KARIs....

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Pubblicato in:Biochem J
Autori principali: Cahn, Jackson K.B., Brinkmann-Chen, Sabine, Spatzal, Thomas, Wiig, Jared A., Buller, Andrew R., Einsle, Oliver, Hu, Yilin, Ribbe, Markus W., Arnold, Frances H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550535/
https://ncbi.nlm.nih.gov/pubmed/25849365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20150183
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