General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH

To date, efforts to switch the cofactor specificity of oxidoreductases from nicotinamide adenine dinucleotide phosphate (NADPH) to nicotinamide adenine dinucleotide (NADH) have been made on a case-by-case basis with varying degrees of success. Here we present a straightforward recipe for altering th...

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Detalhes bibliográficos
Main Authors: Brinkmann-Chen, Sabine, Flock, Tilman, Cahn, Jackson K. B., Snow, Christopher D., Brustad, Eric M., McIntosh, John A., Meinhold, Peter, Zhang, Liang, Arnold, Frances H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704004/
https://ncbi.nlm.nih.gov/pubmed/23776225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1306073110
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