Hypoxia suppresses conversion from proliferative arrest to cellular senescence

door Leontieva, Olga V., Natarajan, Venkatesh, Demidenko, Zoya N., Burdelya, Lyudmila G., Gudkov, Andrei V., Blagosklonny, Mikhail V.
Gepubliceerd in 2012

Secreted transforming growth factor β2 activates NF-κB, blocks apoptosis, and is essential for the survival of some tumor cells

door Lu, Tao, Burdelya, Lyudmila G., Swiatkowski, Shannon M., Boiko, Alexander D., Howe, Philip H., Stark, George R., Gudkov, Andrei V.
Gepubliceerd in 2004

A Flagellin-Derived Toll-Like Receptor 5 Agonist Stimulates Cytotoxic Lymphocyte-Mediated Tumor Immunity

door Leigh, Nicholas D., Bian, Guanglin, Ding, Xilai, Liu, Hong, Aygun-Sunar, Semra, Burdelya, Lyudmila G., Gudkov, Andrei V., Cao, Xuefang
Gepubliceerd in 2014

Mitigation of Radiation-Induced Epithelial Damage by the TLR5 Agonist Entolimod in a Mouse Model of Fractionated Head and Neck Irradiation

door Toshkov, Ilia A., Gleiberman, Anatoli S., Mett, Vadim L., Hutson, Alan D., Singh, Anurag K., Gudkov, Andrei V., Burdelya, Lyudmila G.
Gepubliceerd in Radiat Res (2017)

Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8(+) T-cell axis

door Brackett, Craig M., Kojouharov, Bojidar, Veith, Jean, Greene, Kellee F., Burdelya, Lyudmila G., Gollnick, Sandra O., Abrams, Scott I., Gudkov, Andrei V.
Gepubliceerd in Proc Natl Acad Sci U S A (2016)

Toll-like Receptor 5 Agonist Protects Mice from Dermatitis and Oral Mucositis Caused by Local Radiation: Implications for Head and Neck Cancer Radiotherapy

door Burdelya, Lyudmila G., Gleiberman, Anatoly S., Toshkov, Ilia, Aygun-Sunar, Semra, Bapardekar, Meghana, Manderscheid-Kern, Patricia, Bellnier, David, Krivokrysenko, Vadim I., Feinstein, Elena, Gudkov, Andrei V.
Gepubliceerd in 2011

Toll-like receptor-5 agonist Entolimod broadens the therapeutic window of 5-fluorouracil by reducing its toxicity to normal tissues in mice

door Kojouharov, Bojidar M., Brackett, Craig M., Veith, Jean M., Johnson, Christopher P., Gitlin, Ilya I., Toshkov, Ilia A., Gleiberman, Anatoli S., Gudkov, Andrei V., Burdelya, Lyudmila G.
Gepubliceerd in 2014

TLR5 agonist entolimod reduces the adverse toxicity of TNF while preserving its antitumor effects

door Haderski, Gary J., Kandar, Bojidar M., Brackett, Craig M., Toshkov, Ilia M., Johnson, Christopher P., Paszkiewicz, Geraldine M., Natarajan, Venkatesh, Gleiberman, Anatoli S., Gudkov, Andrei V., Burdelya, Lyudmila G.
Gepubliceerd in PLoS One (2020)

Combined Stimulation of Toll-Like Receptor 5 and NOD1 Strongly Potentiates Activity of NF-κB, Resulting in Enhanced Innate Immune Reactions and Resistance to Salmonella enterica Se...

door Tukhvatulin, Amir I., Gitlin, Ilya I., Shcheblyakov, Dmitry V., Artemicheva, Natalia M., Burdelya, Lyudmila G., Shmarov, Maxim M., Naroditsky, Boris S., Gudkov, Andrei V., Gintsburg, Alexander L., Logunov, Denis Y.
Gepubliceerd in 2013

The Toll-like receptor 5 agonist entolimod suppresses hepatic metastases in a murine model of ocular melanoma via an NK cell-dependent mechanism

door Yang, Hua, Brackett, Craig M., Morales-Tirado, Vanessa Marie, Li, Zezhong, Zhang, Qing, Wilson, Matthew W., Benjamin, Camille, Harris, Wayne, Waller, Edmund K., Gudkov, Andrei V., Burdelya, Lyudmila G., Grossniklaus, Hans E.
Gepubliceerd in Oncotarget (2015)

An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models

door Burdelya, Lyudmila G., Krivokrysenko, Vadim I., Tallant, Thomas C., Strom, Evguenia, Gleiberman, Anatoly S., Gupta, Damodar, Kurnasov, Oleg V., Fort, Farrel L., Osterman, Andrei L., DiDonato, Joseph A., Feinstein, Elena, Gudkov, Andrei V.
Gepubliceerd in Science (2008)

Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-κB-dependent mechanism of p53 suppression in tumors

door Gurova, Katerina V., Hill, Jason E., Guo, Canhui, Prokvolit, Anatoly, Burdelya, Lyudmila G., Samoylova, Eugenia, Khodyakova, Anna V., Ganapathi, Ram, Ganapathi, Mahrukh, Tararova, Natalia D., Bosykh, Dmitry, Lvovskiy, Dmitriy, Webb, Thomas R., Stark, George R., Gudkov, Andrei V.
Gepubliceerd in 2005

A deimmunized and pharmacologically optimized Toll-like receptor 5 agonist for therapeutic applications

door Mett, Vadim, Kurnasov, Oleg V., Bespalov, Ivan A., Molodtsov, Ivan, Brackett, Craig M., Burdelya, Lyudmila G., Purmal, Andrei A., Gleiberman, Anatoli S., Toshkov, Ilia A., Burkhart, Catherine A., Kogan, Yakov N., Andrianova, Ekaterina L., Gudkov, Andrei V., Osterman, Andrei L.
Gepubliceerd in Commun Biol (2021)

Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist

door Burdelya, Lyudmila G., Brackett, Craig M., Kojouharov, Bojidar, Gitlin, Ilya I., Leonova, Katerina I., Gleiberman, Anatoli S., Aygun-Sunar, Semra, Veith, Jean, Johnson, Christopher, Haderski, Gary J., Stanhope-Baker, Patricia, Allamaneni, Shyam, Skitzki, Joseph, Zeng, Ming, Martsen, Elena, Medvedev, Alexander, Scheblyakov, Dmitry, Artemicheva, Nataliya M., Logunov, Denis Y., Gintsburg, Alexander L., Naroditsky, Boris S., Makarov, Sergei S., Gudkov, Andrei V.
Gepubliceerd in 2013