An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models

The toxicity of ionizing radiation is associated with massive apoptosis in radiosensitive organs. Here, we investigate whether a drug that activates a signaling mechanism used by tumor cells to suppress apoptosis can protect healthy cells from the harmful effects of radiation. We studied CBLB502, a...

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Опубликовано в: :Science
Главные авторы: Burdelya, Lyudmila G., Krivokrysenko, Vadim I., Tallant, Thomas C., Strom, Evguenia, Gleiberman, Anatoly S., Gupta, Damodar, Kurnasov, Oleg V., Fort, Farrel L., Osterman, Andrei L., DiDonato, Joseph A., Feinstein, Elena, Gudkov, Andrei V.
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322935/
https://ncbi.nlm.nih.gov/pubmed/18403709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1154986
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