An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models

The toxicity of ionizing radiation is associated with massive apoptosis in radiosensitive organs. Here, we investigate whether a drug that activates a signaling mechanism used by tumor cells to suppress apoptosis can protect healthy cells from the harmful effects of radiation. We studied CBLB502, a...

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發表在:Science
Main Authors: Burdelya, Lyudmila G., Krivokrysenko, Vadim I., Tallant, Thomas C., Strom, Evguenia, Gleiberman, Anatoly S., Gupta, Damodar, Kurnasov, Oleg V., Fort, Farrel L., Osterman, Andrei L., DiDonato, Joseph A., Feinstein, Elena, Gudkov, Andrei V.
格式: Artigo
語言:Inglês
出版: 2008
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322935/
https://ncbi.nlm.nih.gov/pubmed/18403709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1154986
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