A deimmunized and pharmacologically optimized Toll-like receptor 5 agonist for therapeutic applications

The Toll-like receptor 5 (TLR5) agonist entolimod, a derivative of Salmonella flagellin, has therapeutic potential for several indications including radioprotection and cancer immunotherapy. However, in Phase 1 human studies, entolimod induced a rapid neutralizing immune response, presumably due to...

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Detalhes bibliográficos
Publicado no:Commun Biol
Main Authors: Mett, Vadim, Kurnasov, Oleg V., Bespalov, Ivan A., Molodtsov, Ivan, Brackett, Craig M., Burdelya, Lyudmila G., Purmal, Andrei A., Gleiberman, Anatoli S., Toshkov, Ilia A., Burkhart, Catherine A., Kogan, Yakov N., Andrianova, Ekaterina L., Gudkov, Andrei V., Osterman, Andrei L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8041767/
https://ncbi.nlm.nih.gov/pubmed/33846531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01978-6
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