An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models

The toxicity of ionizing radiation is associated with massive apoptosis in radiosensitive organs. Here, we investigate whether a drug that activates a signaling mechanism used by tumor cells to suppress apoptosis can protect healthy cells from the harmful effects of radiation. We studied CBLB502, a...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Burdelya, Lyudmila G., Krivokrysenko, Vadim I., Tallant, Thomas C., Strom, Evguenia, Gleiberman, Anatoly S., Gupta, Damodar, Kurnasov, Oleg V., Fort, Farrel L., Osterman, Andrei L., DiDonato, Joseph A., Feinstein, Elena, Gudkov, Andrei V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322935/
https://ncbi.nlm.nih.gov/pubmed/18403709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1154986
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