The Toll-like receptor 5 agonist entolimod suppresses hepatic metastases in a murine model of ocular melanoma via an NK cell-dependent mechanism

Uveal melanoma (UM) is the most common primary cancer of the eye in adults and progresses to metastatic disease predominantly of the liver in ∼50% of patients. In these cases, life expectancy averages just 9 months due to the lack of effective treatment options. The Toll-like receptor 5 (TLR5) agoni...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Yang, Hua, Brackett, Craig M., Morales-Tirado, Vanessa Marie, Li, Zezhong, Zhang, Qing, Wilson, Matthew W., Benjamin, Camille, Harris, Wayne, Waller, Edmund K., Gudkov, Andrei V., Burdelya, Lyudmila G., Grossniklaus, Hans E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823082/
https://ncbi.nlm.nih.gov/pubmed/26655090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6500
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