Apolipoprotein A-I anti-tumor activity targets cancer cell metabolism

av Zamanian-Daryoush, Maryam, Lindner, Daniel J., Buffa, Jennifer, Gopalan, Banu, Na, Jie, Hazen, Stanley L., DiDonato, Joseph A.
I publikationen Oncotarget (2020)

Myeloperoxidase-mediated protein lysine oxidation generates 2-aminoadipic acid and lysine nitrile in vivo

av Lin, Hongqiao, Levison, Bruce S., Buffa, Jennifer A., Huang, Ying, Fu, Xiaoming, Wang, Zeneng, Gogonea, Valentin, DiDonato, Joseph A., Hazen, Stanley L.
I publikationen Free Radic Biol Med (2017)

(2)H(2)O-Based HDL Turnover Method for the Assessment of Dynamic HDL Function in Mice

av Kasumov, Takhar, Willard, Belinda, Li, Ling, Li, Min, Conger, Heather, Buffa, Jennifer A., Previs, Stephen, McCullough, Arthur, Hazen, Stanley L., Smith, Jonathan D.
Publicerad 2013

Gut Microbiota-Dependent Trimethylamine N-oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

av Wilson Tang, W. H., Wang, Zeneng, Kennedy, David J., Wu, Yuping, Buffa, Jennifer A., Agatisa-Boyle, Brendan, Li, Xinmin S., Levison, Bruce S., Hazen, Stanley L.
I publikationen Circ Res (2014)

Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide

av Wang, Zeneng, Tang, W. H. Wilson, Buffa, Jennifer A., Fu, Xiaoming, Britt, Earl B., Koeth, Robert A., Levison, Bruce S., Fan, Yiying, Wu, Yuping, Hazen, Stanley L.
Publicerad 2014

Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer

av Zamanian-Daryoush, Maryam, Lindner, Daniel J., DiDonato, Joseph A., Wagner, Matthew, Buffa, Jennifer, Rayman, Patricia, Parks, John S., Westerterp, Marit, Tall, Alan R., Hazen, Stanley L.
I publikationen Oncotarget (2017)

Targeted inhibition of gut microbial TMAO production reduces renal tubulointerstitial fibrosis and functional impairment in a murine model of chronic kidney disease

av Gupta, Nilaksh, Buffa, Jennifer A., Roberts, Adam B, Sangwan, Naseer, Skye, Sarah M., Li, Lin, Ho, Karen J., Varga, John, DiDonato, Joseph A., Tang, W.H. Wilson, Hazen, Stanley L.
I publikationen Arterioscler Thromb Vasc Biol (2020)

Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation

av Gregory, Jill C., Buffa, Jennifer A., Org, Elin, Wang, Zeneng, Levison, Bruce S., Zhu, Weifei, Wagner, Matthew A., Bennett, Brian J., Li, Lin, DiDonato, Joseph A., Lusis, Aldons J., Hazen, Stanley L.
I publikationen J Biol Chem (2015)

Site-specific 5-hydroxytryptophan incorporation into apolipoprotein A-I impairs cholesterol efflux activity and high-density lipoprotein biogenesis

av Zamanian-Daryoush, Maryam, Gogonea, Valentin, DiDonato, Anthony J., Buffa, Jennifer A., Choucair, Ibrahim, Levison, Bruce S., Hughes, Randall A., Ellington, Andrew D., Huang, Ying, Li, Xinmin S., DiDonato, Joseph A., Hazen, Stanley L.
I publikationen J Biol Chem (2020)

Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma

av Wang, Zeneng, DiDonato, Joseph A., Buffa, Jennifer, Comhair, Suzy A., Aronica, Mark A., Dweik, Raed A., Lee, Nancy A., Lee, James J., Thomassen, Mary Jane, Kavuru, Mani, Erzurum, Serpil C., Hazen, Stanley L.
I publikationen J Biol Chem (2016)

Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism

av Pathak, Preeti, Helsley, Robert N., Brown, Amanda L., Buffa, Jennifer A., Choucair, Ibrahim, Nemet, Ina, Gogonea, Camelia Baleanu, Gogonea, Valentin, Wang, Zeneng, Garcia-Garcia, Jose Carlos, Cai, Lei, Temel, Ryan, Sangwan, Naseer, Hazen, Stanley L., Brown, J. Mark
I publikationen Am J Physiol Heart Circ Physiol (2020)

γ–Butyrobetaine is a pro-atherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO

av Koeth, Robert A., Levison, Bruce S., Culley, Miranda K., Buffa, Jennifer A., Wang, Zeneng, Gregory, Jill C., Org, Elin, Wu, Yuping, Li, Lin, Smith, Jonathan D., Wilson Tang, W. H., DiDonato, Joseph A., Lusis, Aldons J., Hazen, Stanley L.
I publikationen Cell Metab (2014)

A Systematic Investigation of Structure/Function Requirements for the Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop of High-density Lipoprotein

av Gu, Xiaodong, Wu, Zhiping, Huang, Ying, Wagner, Matthew A., Baleanu-Gogonea, Camelia, Mehl, Ryan A., Buffa, Jennifer A., DiDonato, Anthony J., Hazen, Leah B., Fox, Paul L., Gogonea, Valentin, Parks, John S., DiDonato, Joseph A., Hazen, Stanley L.
I publikationen J Biol Chem (2016)

The Cardioprotective Protein Apolipoprotein A1 Promotes Potent Anti-tumorigenic Effects

av Zamanian-Daryoush, Maryam, Lindner, Daniel, Tallant, Thomas C., Wang, Zeneng, Buffa, Jennifer, Klipfell, Elizabeth, Parker, Yvonne, Hatala, Denise, Parsons-Wingerter, Patricia, Rayman, Pat, Yusufishaq, Mohamed Sharif S., Fisher, Edward A., Smith, Jonathan D., Finke, Jim, DiDonato, Joseph A., Hazen, Stanley L.
Publicerad 2013

Effects of native and myeloperoxidase-modified apolipoprotein A-I on reverse cholesterol transport and atherosclerosis in mice

av Hewing, Bernd, Parathath, Saj, Barrett, Tessa, Chung, Wing Ki Kellie, Astudillo, Yaritzy M., Hamada, Tadateru, Ramkhelawon, Bhama, Tallant, Thomas C., Yusufishaq, Mohamed Shaif S., DiDonato, Joseph A., Huang, Ying, Buffa, Jennifer, Berisha, Stela Z., Smith, Jonathan D., Hazen, Stanley L., Fisher, Edward A.
Publicerad 2014

Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis

av Wang, Zeneng, Roberts, Adam B., Buffa, Jennifer A., Levison, Bruce S., Zhu, Weifei, Org, Elin, Gu, Xiaodong, Huang, Ying, Zamanian-Daryoush, Maryam, Culley, Miranda K., DiDonato, Anthony J., Fu, Xiaoming, Hazen, Jennie E., Krajcik, Daniel, DiDonato, Joseph A., Lusis, Aldons J., Hazen, Stanley L.
I publikationen Cell (2015)

Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk

av Zhu, Weifei, Gregory, Jill C., Org, Elin, Buffa, Jennifer A., Gupta, Nilaksh, Wang, Zeneng, Li, Lin, Fu, Xiaoming, Wu, Yuping, Mehrabian, Margarete, Sartor, R. Balfour, McIntyre, Thomas M., Silverstein, Roy L., Tang, W.H. Wilson, DiDonato, Joseph A., Brown, J. Mark, Lusis, Aldons J., Hazen, Stanley L.
I publikationen Cell (2016)

Gut microbes impact stroke severity via the trimethylamine-N-oxide pathway

av Zhu, Weifei, Romano, Kymberleigh A., Li, Lin, Buffa, Jennifer A., Sangwan, Naseer, Prakash, Prem, Tittle, Aaron N., Li, Xinmin S., Fu, Xiaoming, Androjna, Charlie, DiDonato, Anthony J., Brinson, Kimberly, Trapp, Bruce D., Fischbach, Michael A., Rey, Federico E., Hajjar, Adeline M., DiDonato, Joseph A., Hazen, Stanley L.
I publikationen Cell Host Microbe (2021)

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis

av Koeth, Robert A., Wang, Zeneng, Levison, Bruce S., Buffa, Jennifer A., Org, Elin, Sheehy, Brendan T., Britt, Earl B., Fu, Xiaoming, Wu, Yuping, Li, Lin, Smith, Jonathan D., DiDonato, Joseph A., Chen, Jun, Li, Hongzhe, Wu, Gary D., Lewis, James D., Warrier, Manya, Brown, J. Mark, Krauss, Ronald M., Tang, W. H. Wilson, Bushman, Frederic D., Lusis, Aldons J., Hazen, Stanley L.
Publicerad 2013

Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk

av Li, Xinmin S., Wang, Zeneng, Cajka, Tomas, Buffa, Jennifer A., Nemet, Ina, Hurd, Alex G., Gu, Xiaodong, Skye, Sarah M., Roberts, Adam B., Wu, Yuping, Li, Lin, Shahen, Christopher J., Wagner, Matthew A., Hartiala, Jaana A., Kerby, Robert L., Romano, Kymberleigh A., Han, Yi, Obeid, Slayman, Lüscher, Thomas F., Allayee, Hooman, Rey, Federico E., DiDonato, Joseph A., Fiehn, Oliver, Tang, W.H. Wilson, Hazen, Stanley L.
I publikationen JCI Insight (2018)