Site-specific 5-hydroxytryptophan incorporation into apolipoprotein A-I impairs cholesterol efflux activity and high-density lipoprotein biogenesis

Apolipoprotein A-I (apoA-I) is the major protein constituent of high-density lipoprotein (HDL) and a target of myeloperoxidase-dependent oxidation in the artery wall. In atherosclerotic lesions, apoA-I exhibits marked oxidative modifications at multiple sites, including Trp(72). Site-specific mutage...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Zamanian-Daryoush, Maryam, Gogonea, Valentin, DiDonato, Anthony J., Buffa, Jennifer A., Choucair, Ibrahim, Levison, Bruce S., Hughes, Randall A., Ellington, Andrew D., Huang, Ying, Li, Xinmin S., DiDonato, Joseph A., Hazen, Stanley L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7152772/
https://ncbi.nlm.nih.gov/pubmed/32098873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012092
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