Myeloperoxidase-mediated protein lysine oxidation generates 2-aminoadipic acid and lysine nitrile in vivo

Recent studies reveal 2-aminoadipic acid (2-AAA) is both elevated in subjects at risk for diabetes and mechanistically linked to glucose homeostasis. Prior studies also suggest enrichment of protein-bound 2-AAA as an oxidative post-translational modification of lysyl residues in tissues associated w...

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Published in:Free Radic Biol Med
Main Authors: Lin, Hongqiao, Levison, Bruce S., Buffa, Jennifer A., Huang, Ying, Fu, Xiaoming, Wang, Zeneng, Gogonea, Valentin, DiDonato, Joseph A., Hazen, Stanley L.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353359/
https://ncbi.nlm.nih.gov/pubmed/28069522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.01.006
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