Modification of High Density Lipoprotein by Myeloperoxidase Generates a Pro-inflammatory Particle

High density lipoprotein (HDL) is the major atheroprotective particle in plasma. Recent studies demonstrate that myeloperoxidase (MPO) binds to HDL in vivo, selectively targeting apolipoprotein A1 (apoA1) of HDL for oxidative modification and concurrent loss in cholesterol efflux and lecithin choles...

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Bibliographic Details
Main Authors: Undurti, Arundhati, Huang, Ying, Lupica, Joseph A., Smith, Jonathan D., DiDonato, Joseph A., Hazen, Stanley L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781481/
https://ncbi.nlm.nih.gov/pubmed/19726691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.047605
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