Apolipoprotein A-I anti-tumor activity targets cancer cell metabolism

Por Zamanian-Daryoush, Maryam, Lindner, Daniel J., Buffa, Jennifer, Gopalan, Banu, Na, Jie, Hazen, Stanley L., DiDonato, Joseph A.
Publicado no Oncotarget (2020)

Myeloperoxidase-mediated protein lysine oxidation generates 2-aminoadipic acid and lysine nitrile in vivo

Por Lin, Hongqiao, Levison, Bruce S., Buffa, Jennifer A., Huang, Ying, Fu, Xiaoming, Wang, Zeneng, Gogonea, Valentin, DiDonato, Joseph A., Hazen, Stanley L.
Publicado no Free Radic Biol Med (2017)

(2)H(2)O-Based HDL Turnover Method for the Assessment of Dynamic HDL Function in Mice

Por Kasumov, Takhar, Willard, Belinda, Li, Ling, Li, Min, Conger, Heather, Buffa, Jennifer A., Previs, Stephen, McCullough, Arthur, Hazen, Stanley L., Smith, Jonathan D.
Publicado em 2013

Gut Microbiota-Dependent Trimethylamine N-oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

Por Wilson Tang, W. H., Wang, Zeneng, Kennedy, David J., Wu, Yuping, Buffa, Jennifer A., Agatisa-Boyle, Brendan, Li, Xinmin S., Levison, Bruce S., Hazen, Stanley L.
Publicado no Circ Res (2014)

Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide

Por Wang, Zeneng, Tang, W. H. Wilson, Buffa, Jennifer A., Fu, Xiaoming, Britt, Earl B., Koeth, Robert A., Levison, Bruce S., Fan, Yiying, Wu, Yuping, Hazen, Stanley L.
Publicado em 2014

Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer

Por Zamanian-Daryoush, Maryam, Lindner, Daniel J., DiDonato, Joseph A., Wagner, Matthew, Buffa, Jennifer, Rayman, Patricia, Parks, John S., Westerterp, Marit, Tall, Alan R., Hazen, Stanley L.
Publicado no Oncotarget (2017)

Targeted inhibition of gut microbial TMAO production reduces renal tubulointerstitial fibrosis and functional impairment in a murine model of chronic kidney disease

Por Gupta, Nilaksh, Buffa, Jennifer A., Roberts, Adam B, Sangwan, Naseer, Skye, Sarah M., Li, Lin, Ho, Karen J., Varga, John, DiDonato, Joseph A., Tang, W.H. Wilson, Hazen, Stanley L.
Publicado no Arterioscler Thromb Vasc Biol (2020)

Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation

Por Gregory, Jill C., Buffa, Jennifer A., Org, Elin, Wang, Zeneng, Levison, Bruce S., Zhu, Weifei, Wagner, Matthew A., Bennett, Brian J., Li, Lin, DiDonato, Joseph A., Lusis, Aldons J., Hazen, Stanley L.
Publicado no J Biol Chem (2015)

Site-specific 5-hydroxytryptophan incorporation into apolipoprotein A-I impairs cholesterol efflux activity and high-density lipoprotein biogenesis

Por Zamanian-Daryoush, Maryam, Gogonea, Valentin, DiDonato, Anthony J., Buffa, Jennifer A., Choucair, Ibrahim, Levison, Bruce S., Hughes, Randall A., Ellington, Andrew D., Huang, Ying, Li, Xinmin S., DiDonato, Joseph A., Hazen, Stanley L.
Publicado no J Biol Chem (2020)

Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma

Por Wang, Zeneng, DiDonato, Joseph A., Buffa, Jennifer, Comhair, Suzy A., Aronica, Mark A., Dweik, Raed A., Lee, Nancy A., Lee, James J., Thomassen, Mary Jane, Kavuru, Mani, Erzurum, Serpil C., Hazen, Stanley L.
Publicado no J Biol Chem (2016)

Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism

Por Pathak, Preeti, Helsley, Robert N., Brown, Amanda L., Buffa, Jennifer A., Choucair, Ibrahim, Nemet, Ina, Gogonea, Camelia Baleanu, Gogonea, Valentin, Wang, Zeneng, Garcia-Garcia, Jose Carlos, Cai, Lei, Temel, Ryan, Sangwan, Naseer, Hazen, Stanley L., Brown, J. Mark
Publicado no Am J Physiol Heart Circ Physiol (2020)

γ–Butyrobetaine is a pro-atherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO

Por Koeth, Robert A., Levison, Bruce S., Culley, Miranda K., Buffa, Jennifer A., Wang, Zeneng, Gregory, Jill C., Org, Elin, Wu, Yuping, Li, Lin, Smith, Jonathan D., Wilson Tang, W. H., DiDonato, Joseph A., Lusis, Aldons J., Hazen, Stanley L.
Publicado no Cell Metab (2014)

A Systematic Investigation of Structure/Function Requirements for the Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop of High-density Lipoprotein

Por Gu, Xiaodong, Wu, Zhiping, Huang, Ying, Wagner, Matthew A., Baleanu-Gogonea, Camelia, Mehl, Ryan A., Buffa, Jennifer A., DiDonato, Anthony J., Hazen, Leah B., Fox, Paul L., Gogonea, Valentin, Parks, John S., DiDonato, Joseph A., Hazen, Stanley L.
Publicado no J Biol Chem (2016)

The Cardioprotective Protein Apolipoprotein A1 Promotes Potent Anti-tumorigenic Effects

Por Zamanian-Daryoush, Maryam, Lindner, Daniel, Tallant, Thomas C., Wang, Zeneng, Buffa, Jennifer, Klipfell, Elizabeth, Parker, Yvonne, Hatala, Denise, Parsons-Wingerter, Patricia, Rayman, Pat, Yusufishaq, Mohamed Sharif S., Fisher, Edward A., Smith, Jonathan D., Finke, Jim, DiDonato, Joseph A., Hazen, Stanley L.
Publicado em 2013

Effects of native and myeloperoxidase-modified apolipoprotein A-I on reverse cholesterol transport and atherosclerosis in mice

Por Hewing, Bernd, Parathath, Saj, Barrett, Tessa, Chung, Wing Ki Kellie, Astudillo, Yaritzy M., Hamada, Tadateru, Ramkhelawon, Bhama, Tallant, Thomas C., Yusufishaq, Mohamed Shaif S., DiDonato, Joseph A., Huang, Ying, Buffa, Jennifer, Berisha, Stela Z., Smith, Jonathan D., Hazen, Stanley L., Fisher, Edward A.
Publicado em 2014

Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis

Por Wang, Zeneng, Roberts, Adam B., Buffa, Jennifer A., Levison, Bruce S., Zhu, Weifei, Org, Elin, Gu, Xiaodong, Huang, Ying, Zamanian-Daryoush, Maryam, Culley, Miranda K., DiDonato, Anthony J., Fu, Xiaoming, Hazen, Jennie E., Krajcik, Daniel, DiDonato, Joseph A., Lusis, Aldons J., Hazen, Stanley L.
Publicado no Cell (2015)

Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk

Por Zhu, Weifei, Gregory, Jill C., Org, Elin, Buffa, Jennifer A., Gupta, Nilaksh, Wang, Zeneng, Li, Lin, Fu, Xiaoming, Wu, Yuping, Mehrabian, Margarete, Sartor, R. Balfour, McIntyre, Thomas M., Silverstein, Roy L., Tang, W.H. Wilson, DiDonato, Joseph A., Brown, J. Mark, Lusis, Aldons J., Hazen, Stanley L.
Publicado no Cell (2016)

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis

Por Koeth, Robert A., Wang, Zeneng, Levison, Bruce S., Buffa, Jennifer A., Org, Elin, Sheehy, Brendan T., Britt, Earl B., Fu, Xiaoming, Wu, Yuping, Li, Lin, Smith, Jonathan D., DiDonato, Joseph A., Chen, Jun, Li, Hongzhe, Wu, Gary D., Lewis, James D., Warrier, Manya, Brown, J. Mark, Krauss, Ronald M., Tang, W. H. Wilson, Bushman, Frederic D., Lusis, Aldons J., Hazen, Stanley L.
Publicado em 2013

Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk

Por Li, Xinmin S., Wang, Zeneng, Cajka, Tomas, Buffa, Jennifer A., Nemet, Ina, Hurd, Alex G., Gu, Xiaodong, Skye, Sarah M., Roberts, Adam B., Wu, Yuping, Li, Lin, Shahen, Christopher J., Wagner, Matthew A., Hartiala, Jaana A., Kerby, Robert L., Romano, Kymberleigh A., Han, Yi, Obeid, Slayman, Lüscher, Thomas F., Allayee, Hooman, Rey, Federico E., DiDonato, Joseph A., Fiehn, Oliver, Tang, W.H. Wilson, Hazen, Stanley L.
Publicado no JCI Insight (2018)

Development of a gut microbe-targeted non-lethal therapeutic to inhibit thrombosis potential

Por Roberts, Adam B., Gu, Xiaodong, Buffa, Jennifer A., Hurd, Alex G., Wang, Zeneng, Zhu, Weifei, Gupta, Nilaksh, Skye, Sarah M., Cody, David B., Levison, Bruce S., Barrington, William T., Russel, Matthew W., Reed, Jodie M., Duzan, Ashraf, Lang, Jennifer M., Fu, Xiaoming, Li, Lin, Myers, Alex J., Rachakonda, Suguna, DiDonato, Joseph A., Brown, J. Mark, Gogonea, Valentin, Lusis, Aldons J., Garcia-Garcia, Jose Carlos, Hazen, Stanley L.
Publicado no Nat Med (2018)