γ–Butyrobetaine is a pro-atherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO

L- Carnitine, a nutrient in red meat, was recently reported to accelerate atherosclerosis via a metaorganismal pathway involving gut microbial trimethylamine (TMA) formation and host hepatic conversion into trimethylamine-N-oxide (TMAO). Herein we show that following L-carnitine ingestion, γ-butyrob...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Koeth, Robert A., Levison, Bruce S., Culley, Miranda K., Buffa, Jennifer A., Wang, Zeneng, Gregory, Jill C., Org, Elin, Wu, Yuping, Li, Lin, Smith, Jonathan D., Wilson Tang, W. H., DiDonato, Joseph A., Lusis, Aldons J., Hazen, Stanley L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255476/
https://ncbi.nlm.nih.gov/pubmed/25440057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.10.006
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