l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans

BACKGROUND.l-Carnitine, an abundant nutrient in red meat, accelerates atherosclerosis in mice via gut microbiota–dependent formation of trimethylamine (TMA) and trimethylamine N-oxide (TMAO) via a multistep pathway involving an atherogenic intermediate, γ-butyrobetaine (γBB). The contribution of γBB...

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Bibliografski detalji
Izdano u:J Clin Invest
Glavni autori: Koeth, Robert A., Lam-Galvez, Betzabe Rachel, Kirsop, Jennifer, Wang, Zeneng, Levison, Bruce S., Gu, Xiaodong, Copeland, Matthew F., Bartlett, David, Cody, David B., Dai, Hong J., Culley, Miranda K., Li, Xinmin S., Fu, Xiaoming, Wu, Yuping, Li, Lin, DiDonato, Joseph A., Tang, W.H. Wilson, Garcia-Garcia, Jose Carlos, Hazen, Stanley L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2018
Teme:
Clinical Medicine
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307959/
https://ncbi.nlm.nih.gov/pubmed/30530985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94601
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