l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans

BACKGROUND.l-Carnitine, an abundant nutrient in red meat, accelerates atherosclerosis in mice via gut microbiota–dependent formation of trimethylamine (TMA) and trimethylamine N-oxide (TMAO) via a multistep pathway involving an atherogenic intermediate, γ-butyrobetaine (γBB). The contribution of γBB...

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Udgivet i:J Clin Invest
Main Authors: Koeth, Robert A., Lam-Galvez, Betzabe Rachel, Kirsop, Jennifer, Wang, Zeneng, Levison, Bruce S., Gu, Xiaodong, Copeland, Matthew F., Bartlett, David, Cody, David B., Dai, Hong J., Culley, Miranda K., Li, Xinmin S., Fu, Xiaoming, Wu, Yuping, Li, Lin, DiDonato, Joseph A., Tang, W.H. Wilson, Garcia-Garcia, Jose Carlos, Hazen, Stanley L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Clinical Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307959/
https://ncbi.nlm.nih.gov/pubmed/30530985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94601
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