Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N-oxide, a Pro-Atherogenic Metabolite of Choline and L-Carnitine

OBJECTIVE: Elevated levels of plasma trimethyl amine N-oxide (TMAO), the product of gut microbiome and hepatic-mediated metabolism of dietary choline and L-carnitine, have recently been identified as a novel risk factor for the development of atherosclerosis in mice and humans. The goals of this stu...

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Detalhes bibliográficos
Main Authors: Hartiala, Jaana, Bennett, Brian J., Wilson Tang, W. H., Wang, Zeneng, Stewart, Alexandre F. R., Roberts, Robert, McPherson, Ruth, Consortium, CARDIoGRAM, Lusis, Aldons J., Hazen, Stanley L., Allayee, Hooman
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035110/
https://ncbi.nlm.nih.gov/pubmed/24675659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.114.303252
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