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Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

Circulating trimethylamine-N-oxide (TMAO) levels are strongly associated with atherosclerosis. We now examine genetic, dietary, and hormonal factors regulating TMAO levels. We demonstrate that two flavin monooxygenase family members, FMO1 and FMO3, oxidize trimethylamine (TMA), derived from gut flor...

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Bibliografiske detaljer
Main Authors: Bennett, Brian J., de Aguiar Vallim, Thomas Q., Wang, Zeneng, Shih, Diana M., Meng, Yonghong, Gregory, Jill, Allayee, Hooman, Lee, Richard, Graham, Mark, Crooke, Rosanne, Edwards, Peter A., Hazen, Stanley L., Lusis, Aldons J.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771112/
https://ncbi.nlm.nih.gov/pubmed/23312283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.12.011
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