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Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

Circulating trimethylamine-N-oxide (TMAO) levels are strongly associated with atherosclerosis. We now examine genetic, dietary, and hormonal factors regulating TMAO levels. We demonstrate that two flavin monooxygenase family members, FMO1 and FMO3, oxidize trimethylamine (TMA), derived from gut flor...

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Detalhes bibliográficos
Main Authors: Bennett, Brian J., de Aguiar Vallim, Thomas Q., Wang, Zeneng, Shih, Diana M., Meng, Yonghong, Gregory, Jill, Allayee, Hooman, Lee, Richard, Graham, Mark, Crooke, Rosanne, Edwards, Peter A., Hazen, Stanley L., Lusis, Aldons J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771112/
https://ncbi.nlm.nih.gov/pubmed/23312283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.12.011
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