Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

BACKGROUND: The choline‐derived metabolite trimethylamine N‐oxide (TMAO) has been demonstrated to contribute to atherosclerosis and is associated with coronary artery disease risk. METHODS AND RESULTS: We explored the impact of TMAO on endothelial and smooth muscle cell function in vivo, focusing on...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Seldin, Marcus M., Meng, Yonghong, Qi, Hongxiu, Zhu, WeiFei, Wang, Zeneng, Hazen, Stanley L., Lusis, Aldons J., Shih, Diana M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4802459/
https://ncbi.nlm.nih.gov/pubmed/26903003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.002767
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