Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis

We performed silencing and overexpression studies of flavin containing monooxygenase (FMO) 3 in hyperlipidemic mouse models to examine its effects on trimethylamine N-oxide (TMAO) levels and atherosclerosis. Knockdown of hepatic FMO3 in LDL receptor knockout mice using an antisense oligonucleotide r...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Shih, Diana M., Wang, Zeneng, Lee, Richard, Meng, Yonghong, Che, Nam, Charugundla, Sarada, Qi, Hannah, Wu, Judy, Pan, Calvin, Brown, J. Mark, Vallim, Thomas, Bennett, Brian J., Graham, Mark, Hazen, Stanley L., Lusis, Aldons J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274068/
https://ncbi.nlm.nih.gov/pubmed/25378658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M051680
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